伯纳德·P. Possidente
Professor of Biology @ Skidmore since 1983
地址:
Department of Biology - CIS 110i
火博体育大学
萨拉托加温泉市, New York 12866
电话:
518-580-5082
传真:
518-580-5071
电子邮件: bposside@zizhanggui.com
教育:
- B.A., Wesleyan University
- Ph.D.爱荷华大学
- Postdoctorate, Florida State University
课程:
- Advanced Topics in Genetics (BI 352)
- 遗传学(BI 245)
- Biological Clocks (BI 344)
- Genes and Generation (SSP-008 First Year Seminar)
- Human Genetics (BI 170)
Tiffany Benway '08 and 伯纳德·Possidente
Project: "Biological Clock Function in a 果蝇 Model
of Alzheimer's Disease"
of Alzheimer's Disease"
This research is a collaboration with Dr. Damian Crowther, Cambridge
University, UK Department of Genetics,who made transgenic fly lines
with copies of mutant human genes associated with Alzheimer's.
University, UK Department of Genetics,who made transgenic fly lines
with copies of mutant human genes associated with Alzheimer's.
(Photo by Mark McCarty)
主要研究方向:
Dr. Possidente's general research area is genetic analysis of behavioral mechanisms. His research focuses on the function of biological clocks in controlling circadian (daily-endogenous) rhythms using mice and fruitflies as model systems: manipulation of rhythms in mice and fruitflies with genetic, pharmacological, and photoperiod treatments inorder to identify functional properties of circadian system components and their physiological mechanisms.
Recent Circadian Publications: (*Indicates student co-author)
- LLabre JE, Gil C*, Amatya N*, Lagalwar S, Possidente B, Vashishth D. (2022) Degradation of Bone Quality in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Bone and Mineral Research.
- Nagare R., Possidente B.拉加尔瓦尔，S. 菲格罗先生. (2020) Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model. 《火博体育》第10期，第11期. http://www.nature.com/articles/s41598-020-68199-5.
- Kohiyama M*, Bonser D, Leung L*, Fall A*, Canada N*, Qu B, Ahmad S, Possidente B (2019) The 果蝇 apterous56f mutation impairs circadian locomotor activity. Biol Rhythm Res, 46:275-285.
- Sheppard A, Hirsch HVB, Possidente B, (2015) Novel Masking Effects of Light Are Revealed in 果蝇 by Skeleton Photoperiods. Biological Rhythms Research, 46 (2) 275-285.
- 陈取位, Possidente B, Lomas DA, Crowther DC (2014) The Central Molecular Clock Is Robust in the Face of Behavioural Arrhythmia in a Fly Model of Alzheimer’s Disease. Disease Models and Mechanisms (开放获取 http://dmm.biologists.org/), doi: 10.1242 /数字.014134.
- Hagenauer MH, King AF, Possidente B, McGinnis MY, Lumia AR,Lee TM. (2010) Changes in Circadian Rhythms 在青春期 鼠形: Developmental time course and gonadal dependency. Hormones and Behavior, 60(1):46-57.
- Ruden DM, Chem L, Rasouli P, Wang L, Lu X, Garfinkel MD, Possidente D, Possidente B, Hirsch HVB, Page GP (2009) Genetical toxicogenomics in 果蝇 identifies master modulatory loci that are regualted by developmental exposure to 引领. NeuroToxicology, 30:898-914.
- Hirsch HVB, Possidente D, Averill S, Despain J, Buytkins J, Thomas V, Goebel P, Shipp-Hilts A, Hollocher K, Wilson D, Possidente B and D Rudin (2009) Behavioral QTL after Developmental Exposure of 果蝇 melanogaster to Lead. NeuroToxicology 30:305-311.
- Possidente B. (2007) Genetics and The Sopranos. Letters, Science 317:596.